Grahame Hardie
University of Dundee, United Kingdom
Grahame Hardie became Professor of Cellular Signalling at Dundee University in 1994. He is a Fellow of the Royal Society, the Royal Society of Edinburgh, and the Academy of Medical Sciences. He was awarded the Rolf Luft prize for Endocrinology and Metabolism of the Karolinska Institute (2008), the Novartis Medal (2010) and Philip Randle Prize Lecture (2022) of the UK Biochemical Society, and the Solomon Berson Distinguished Lectureship of the American Physiological Society (2015). He has received an honorary degree from the Medical University of Bialystok, Poland, and was a Distinguished Visiting Professor at the Universities of Hong Kong and Xiamen, China. He originally defined the AMP-activated protein kinase (AMPK) system and demonstrated that it maintained energy balance at the cellular and whole-body levels. He discovered that the tumour suppressor LKB1 acted upstream of AMPK, which led to the current worldwide interest in the role of AMPK in cancer.